Adhesion Class GPCRs in GtoPdb v.2023.1

Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to Class B GPCR, but which is linked 7TM region by GPCR autoproteolysis-inducing (GAIN) domain [10] containing proteolysis site (GPS). The N-terminal often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions leading term adhesion [104, 418]. Several receptors have been suggested function as mechanosensors [320, 288, 396, 38]. Cryo-EM structures 7-transmembrane several determined recently [292, 21, 403, 212, 300, 302, 431, 293]. nomenclature these was revised in 2015 recommended NC-IUPHAR Consortium [125].